A PROSPECTIVE STUDY ON THE ROLE OF VITAMIN D DEFICIENCYIN CHILDREN BORN WITH MACROSOMIA

Abstract

Relevance: Macrosomia is defined as a birth weight of more than 4000 g regardless of gestational age and occurs in 3-
15% of all pregnancies worldwide [2,8,25]. Vitamin D deficiency during pregnancy is associated with an increased risk of
gestational diabetes and preeclampsia, which may indirectly affect the health of offspring [3,4,18].
Objective: To assess the role of vitamin D, the health status of children born with macrosomia in the first year of life.
Materials and methods of research: a prospective study. The study was conducted in the period from January 2021 to
April 2021 at the clinical base "Semey Perinatal Center". The study included full-term newborns in the number of 258
children. Informational consents were received from mothers of newborns to participate in the study. The mothers were
informed about the processing of the received data, with the subsequent publication of the research results, without
specifying personal data. Inclusion criteria: full-term children with macrosomia. Exclusion criteria: children with defects,
genetic diseases, premature newborns.
The data analysis was carried out using the SPSS package version 20.0. To check the statistical significance of the
differences between the group of "cases" and "controls", the Pearson and Fisher criterion χ2 was used, and the odds ratio is
calculated taking into account the 95% confidence interval. Continuous data is presented in the form of (Me) and standard
deviation (CD).
Results: Based on the analysis of the features of early adaptation of newborns with vitamin D deficiency and their health
status in the first year of life. The study showed that the pronounced vitamin D deficiency in serum was significantly lower in
patients with macrosomia compared to normal-weight children.
Conclusion: Thus, according to the results of our study, the early adaptation of newborn children with macrosomia was
manifested with significant differences from children with normal weight. In a prospective follow-up of children with
macrosomia, paratrophy was also noted in the first year of life.