COGNITIVE IMPAIRMENT IN PATIENTS WITH CHRONIC VIRALHEPATITIS IN THE TURKESTAN REGION
DOI:
https://doi.org/10.34689/kqke4e70Keywords:
chronic viral hepatitis , fibrosis , cirrhosis , cognitive impairment , MoCaAbstract
Introduction. Cognitive disorders in patients with chronic viral hepatitis can develop at different times after infection, due
to their direct and indirect neurotoxic effects on the brain. In 50% of those infected with chronic viral hepatitis C, both clinical
and subclinical manifestations of cognitive dysfunction can be detected. Timely diagnosis of cognitive disorders in patients with chronic viral hepatitis can serve as an indication for timely therapeutic measures aimed at improving the quality of life in
this category of patients. This article discusses cognitive disorders in patients with chronic viral hepatitis in the Turkestan
region.
Purpose: to study the qualitative and quantitative characteristics of cognitive functions in chronic viral hepatitis, with an
assessment of the relationship between the severity of cognitive disorders between the stages of liver fibrosis and the
duration of the disease, which are registered in the Regional Hepatological Center of Shymkent.
Material and methods. Prospective cohort study. 149 patients with chronic viral hepatitis registered at the Regional
Hepatological Center in Shymkent were examined. The analysis of cognitive status was carried out using the Montreal Scale
of Cognitive Functions of the MoCa. We used descriptive statistics, the Shapiro-Wilk statistical test, and correlation analysis
using the nonparametric Spearman test for two linear variables.
Results and discussions. The results of the correlation analysis showed a weak negative relationship (r=-0.43, p <
0.04) between the MoСa parameters and the stage of liver fibrosis, which indicates moderate cognitive impairment in chronic
viral hepatitis.
Conclusions. In patients with chronic viral hepatitis at various stages of fibrosis, in most cases, visual-constructive and
executive skills, attention, short-term memory, and abstract thinking were impaired. The establishment of cognitive
dysfunction of various degrees of severity, in particular at an early stage in patients with chronic viral hepatitis, contributes to
the timely implementation of therapeutic measures aimed at improving the quality of life.
References
Полукчи Т.В., Славко Е.А., Абуова Г.Н., Касымова Т.В. Когнитивные нарушения у больных хроническими
вирусными гепатитами в Туркестанской области // Наука и Здравоохранение. 2022. 2(Т.24). С. 71-77. doi
10.34689/SH.2022.24.2.009
Polukchi T.V., Slavko Ye.A., Abuova G.N., Kasymova T.V. Cognitive impairment in patients with chronic viral hepatitis in
the Turkestan region // Nauka i Zdravookhranenie [Science & Healthcare]. 2022, (Vol.24) 2, pp. 71-77. doi
10.34689/SH.2022.24.2.009
Полукчи Т.В., Славко Е.А., Абуова Г.Н., Касымова Т.В. Түркістан облысындағы созылмалы вирустық
гепатиттермен ауыратын науқастарда когнитивті функциялардың бұзылуы // Ғылым және Денсаулық сақтау. 2022.
2 (Т.24). Б. 71-77. doi 10.34689/SH.2022.24.2.009
Downloads
Published
License
Copyright (c) 2026 Татьяна Полукчи, Елена Славко, Гульжан Абуова, Татьяна Касымова (Автор)
This work is licensed under a Creative Commons Attribution 4.0 International License.