EOSINOPHILIC CATIONIC PROTEIN IN PATIENTSWITH ALLERGIC RHINITIS

Abstract

Relevance: Allergic rhinitis is a common disease of the upper respiratory tract, which causes great damage to the quality
of life of patients. Allergic rhinitis often remains undiagnosed, resulting in improper treatment. As a result, patients experience
severity of the condition and development of complications.
In upper respiratory tract diseases, the content of eosinophils in the blood increases. Eosinophils contain several major
proteins, the best known being eosinophilic cationic protein. Eosinophilic cationic protein (ECP) often defined with blood
eosinophilia in allergic upper respiratory tract diseases. Furthermore, eosinophilic cationic protein is use for monitor allergic
diseases.
Objective: To analyze articles describing studies of the level of eosinophilic cationic protein and the content of
eosinophils in nasal secretions, saliva and blood serum in patients with allergic rhinitis. 

Research strategy. Literature was searched in the electronic databases PubMed, GoogleScholar and e-library for
keywords (eosinophilic cationic protein, eosinophils, allergic rhinitis). The search depth was 10 years (from 2008 to 2018).
Relevant works reflecting the characteristics of the problem were taken for description in the review.
Results: An analysis of the articles showed the importance of studying the level of eosinophilic cationic protein in nasal
secretions, saliva and blood serum in patients with allergic rhinitis. ECP can be actively used in the diagnosis of allergic
diseases, evaluating the therapeutic effect as a biomarker. However, despite numerous studies of the relationship between
increased ECP in allergic rhinitis, the question of correlating the level of ECP with the severity of the disease remains little
studied.
Conclusion: Thus, allergic respiratory diseases, such as allergic rhinitis and asthma, are closely related to eosinophils,
which infiltrate local tissue. ECP can be actively used in the diagnosis of allergic diseases, evaluating the therapeutic effect
as a biomarker. However, despite numerous studies of the relationship between increased ECP in allergic rhinitis, the
question of correlating the level of ECP with the severity of the disease remains little studied.