CYTOKINE GENE POLYMORPHISM WITH MYOCARDIALINFARCTION IN SUBJECTS OF RUSSIAN NATIONALITY

Abstract

Objective: This article considers the study of the frequency of allelic variants and genotypes of
cytokines (TNF-α, IL-10, IL-6) in patients of acute myocardial infarction with segment elevation ST
(STEMI) in subjects of Russian nationality.
Materials and Methods: The polymorphism of cytokine genes was examined by restriction analysis
of specific areas of the genome amplification products in 41 (69.5%) men and 18 (30.5%) women of
Russian nationality. Control group was consisted of 75 healthy subjects (donors of Russian nationality).
In all subjects were studied single nucleotide polymorphism SNP-gene promoter region TNF-α (G308A), IL-10 (G-1082A), IL-6 (G-174C). STEMI diagnosis was for accordance with the classification of
the European Society of Cardiology (ESC). All patients were divided into 2 groups, where the group of
uncomplicated STEMI amounted to 34 (57.6%) patients who did not have complications, both in hospital
period and posthospital period. The second group was consisted of 25 (42.4%) patients with
complicated course of STEMI.
Results: In this paper shows, the association of the homozygous genotype minor type A / A in the
position of G-308A promoter region of the TNFα gene with complicated STEMI (OR = 6,72, p<0.05). It
was revealed that the minor type homozygous genotype C / C position of G-174C promoter region of the
gene IL-6 is also associated with complicated STEMI (OR = 3,25, p<0.05). According to our results,
there were no significant differences in the frequency of alleles and genotypes of polymorphism G1082A gene IL-10, depending on the course of STEMI. Thus, polymorphisms of cytokine genes could
be considered as a possible genetic risk factor for morbidity in patients with STEMI of Russian
nationality (East Kazakhstan region of the Republic of Kazakhstan), after further study, with a significant
increase the size of sample