HYPERHOMOCYSTEINEMIA AS A RISK FACTOROF CARDIOVASCULAR DISEASES

Abstract

Cardiovascular diseases are the leading cause of death. In this regard, the importance of the
prevention problem increases, which is aimed at the identification and elimination of risk factors, which
include elevated levels of homocysteine in the blood.
In recent years, actively studying the possibility of the use of B vitamins in vascular and
neurodegenerative diseases. One of the main factors of hyperhomocysteinemia is the deficiency of
vitamins B6, B12, B9 resulting from the features of the diet and impaired absorption. It was found that
the use of preparations of B vitamins can reduce hyperhomocysteinemia in the blood. On the basis of
the theory of homocysteic atherosclerosis development the presence of possible association
hyperhomocysteinemia with the vascular disease formation is explained. It was found that the use of
high doses of B vitamins contribute to a significant reduction in the progression of atherosclerosis in the
early stages.
The article describes the role of hyperhomocysteinemia as a risk factor for cardiovascular disease. A
review of the evidence base and domestic research is prepared. The conclusions recognizing regional
specificities and influence of radiation factor are drawn.
Objective: To conduct a literature search on the study of hyperhomocysteinemia as a risk factor for
cardiovascular disease.
Materials and methods: To achieve this goal was performed a systematic literature search in an
online resource. 278 sources were found of which 63 sources were selected for subsequent analysis.
Key points forming search queries to search for literature were presented to the following elements:
homocysteine, vitamin B, folic acid, cardiovascular risk.
Results and conclusions: For high-risk patients, which include patients with personal or family
history of early cardiovascular failure, and those with malnutrition (reduced absorption syndrome),
hypothyroidism, kidney disease, systemic lupus erythematosus; taking drugs such as nicotinic acid,
theophylline, methotrexate dopamine, and those who are exposed to nitric oxide, it is necessary to carry
out the definition of plasma homocysteine.