REDUCTION OF CONGENITAL MALFORMATIONFREQUENCY ACCORDING TO THE DATA OF GENETICSERVICE OF PERINATAL CENTER OF SEMEY CITYFROM 2010 TO THE FIRST HALF OF 2015

Abstract

Congenital malformations (CM) are heterogenic group of pathological states which include isolated,
system and multiple abnormalities of organs and systems of different etiology: genetic, environmental
and multifactorial [6]. CMs are serious medical and social problem that related to increase of specific
weight of abnormal development in structure of perinatal child mortality and disability. Among newborns,
frequency of CM defined during the first year of life reaches 5%. [8]. CM are leaders in reason structure
of perinatal mortality.
The aim of research is study of statistical data of CM in regions of East Kazakhstan district attached
to perinatal center of Semey for the period from 2010 to the first half of 2015.
Materials and methods: Ultrasound investigations data of pregnant women performed from 2010 to
the first half of 2015 were studied. These ultrasound investigations were performed in regions of East
Kazakhstan district attached to perinatal center of Semey (Semey, Kurchatov, Abay, Ayagoz, Urdzhar,
Beskaragay and Boroduliha regions). Retrospective data presented by the National Genetic Register of
the Republic of Kazakhstan were studied during the investigation. Statistical and analytical methods
were practiced.
Structure of CM in studied region was analyzed. For this purpose, dynamic series of noted indicators
were composed and calculation of IDD (intrauterine developmental defect) specific weight factors was
made.
Results and discussion: In consequence of conducted work enhancement of some factors in 2015
in comparison with 2010 was detected. Frequency of EVM raised from 45 to 98%, reduction of ENM
number was observed. Number of abnormalities of blood circulatory system, central nervous system
and chromosomal abnormalities reduced in structure of СM factor. However, high frequency of
dissemination of musculoskeletal system pathology in comparison with other CM was observed. In East
Kazakhstan district high frequency of dissemination of congenital malformation of heart, vessels
(16,0%), urogenital system (13,7) was registered.