EFFICACY OF PHOTODYNAMIC THERAPY IN THE TREATMENT OF CERVICAL PRECANCEROUS CONDITIONS CAUSED BY HUMAN PAPILLOMAVIRUS
DOI:
https://doi.org/10.34689/acfh7818Keywords:
photodynamic therapy, human papillomavirus infection, squamous intraepithlial lesion, cervixAbstract
Relevance: PDT is a high-tech treatment that uses a combination of a photosensitizer, light and molecular oxygen. The method is based on the mechanisms of free radical oxidation, disruption of the vascular stroma of tumors and elimination under the influence of immune cells. It is a non-invasive, effective and safe treatment that damages and destroys structures in the affected area. However, to normalize the immune response, ensuring a stable regression of carcinogenesis, prolonged elimination of HPV is necessary. Aim: to assess the status of various levels of tissue damage in cervical dysplasia in combination with PVI, using PDT as the main method of treatment. Search strategy: In this study, indicators of the state of the organ, tissue, cellular and molecular levels are used to assess the course of PVI of the cervix. The role of the immune response in HPV-associated precancerous diseases of the cervix is considered. The article presents work on the treatment of dysplasia of varying degrees associated with HPV in 92 patients over a two-year period using PDT. Results: The use of photodynamic therapy in women with HPV-associated cervical precancerous disease is a promising area of research. The results of the work link the role of TLRs with the development of squamous intraepithelial lesions (SIL). Further clinical studies are needed to evaluate efficacy, safety and optimal timing.
References
Khangeldi A.Yе., Khamidullina Z.G., Shanazarov N.A., Afanasyev M.S., Grishache T.G., Akkazhiyeva N.N., Tanysheva G.A. Efficacy of Photodynamic Therapy in the Treatment of Cervical Precancerous Conditions Caused by Human Papillomavirus // Nauka i Zdravookhranenie [Science & Healthcare]. 2025. Vol.27 (3), pp. 53-63. doi 10.34689/SH.2025.27.3.006
Хангелді А.Е., Хамидуллина З.Г., Шаназаров Н.А., Афанасьев М.С., Гришачева Т.Г., Аккажиева Н.Н., Танышева Г.А. Эффективность фотодинамической терапии в лечении предраковых состояний шейки матки, вызванных вирусом папилломы человека // Наука и Здравоохранение. 2025. Т.27 (3), С. 53-63. doi: 10.34689/SH.2025.27.3.006
Хангелді А.Е., Хамидуллина З.Г., Шаназаров Н.А., Афанасьев М.С., Гришачева Т.Г., Аккажиева Н.Н.,Танышева Г.А. HPV тудырған жатыр мойнының ісік алды жағдайларын емдеудегі фотодинамикалық терапияның тиімділігі // Ғылым және Денсаулық. 2025. Т.27 (3), Б. 53-63. doi: 10.34689/SH.2025.27.3.006
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