GENETIC SUSCEPTIBILITY TO RADIATION-RELATED DISEASES: A REVIEW OF CURRENT LITERATURE
DOI:
https://doi.org/10.34689/v89dk261Keywords:
genetic susceptibility, radiosensitivity, ionizing radiation, GWASAbstract
This review aims to synthesize current knowledge on genetic determinants of radiosensitivity, emphasizing findings from candidate gene studies and genome-wide association studies (GWAS), and discuss their clinical implications. Methods: We conducted a literature-based analysis of genetic polymorphisms associated with radiation-related outcomes, focusing on genes involved in DNA repair, cell cycle regulation, oxidative stress response, and tissue remodeling. Results: Variants in genes such as XRCC1, XRCC3, TP53, TGFβ1, and SOD2 have been linked to increased radiosensitivity and risk of adverse outcomes following radiation exposure. GWAS have identified novel loci (TANC1, RAD51L1, KIF26B) associated with normal tissue toxicity and secondary malignancies. While promising, most findings require further validation in diverse populations and clinical settings. Conclusion: Understanding genetic susceptibility to radiation is essential for advancing personalized radiotherapy and improving public health strategies. Future research should prioritize multi-locus models, functional validation, and the ethical integration of genetic data into clinical and occupational contexts
References
Dyussupov A.A., Abildinova G.Zh., Shabdarbayeva D.M., Massabayeva M.R., Pivina L.M., Orekhov A.Yu., Lipikhina A.V., Smailova Zh.K., Kisina R., Alibayeva G.A., Orazalina A.S., Yesentayeva A.M., Sabitova V.R., Baibussinova A.Zh., Qasymov A.B., Klivenko A., Abenova M.B., Ygyyeva D.G, Apbasova S.A., Lepesbayev M.N., Shaizhunussova N.Zh. Genetic susceptibility to radiation-related diseases: a review of current literature // Nauka i Zdravookhranenie [Science & Healthcare]. 2025. Vol.27 (2), pp. 145-153. doi 10.34689/SH.2025.27.2.017
Дюсупов А.А., Абильдинова Г.Ж., Шабдарбаева Д.М., Масабаева М.Р., Пивина Л.М., Орехов А.Ю., Липихина А.В., Смаилова Ж.К., Кисина Р., Алибаева Г.А., Оразалина А.С., Есентаева А.М., Сабитова В.Р., Байбусинова А.Ж., Касымов А., Кливенко А., Абенова М.Б., Ыгыева Д., Апбасова С.А., Лепесбаев М., Чайжунусова Н.Ж. Генетическая предрасположенность к заболеваниям, связанным с радиационным воздействием: обзор современной литературы // Наука и Здравоохранение. 2025. Т.27 (2), С. 145–153. doi: 10.34689/SH.2025.27.2.017
Дюсупов А.А., Абильдинова Г.Ж., Шабдарбаева Д.М., Масабаева М.Р., Пивина Л.М., Орехов А.Ю., Липихина А.В., Смаилова Ж.К., Кисина Р., Алибаева Г.А., Оразалина А.С., Есентаева А.М., Сабитова В.Р., Байбусинова А.Ж., Касымов А., Кливенко А., Абенова М.Б., Ыгыева Д., Апбасова С.А., Лепесбаев М., Чайжунусова Н.Ж. Радиациялық әсерге байланысты ауруларға генетикалық бейімділік: қазіргі әдебиеттерге шолу // Ғылым және Денсаулық. 2025. Т.27 (2), Б.145–153. doi: 10.34689/SH.2025.27.2.017
Downloads
Published
License
Copyright (c) 2025 Рецензируемый медицинский научно-практический журнал «Наука и здравоохранение»
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.