ASSESSMENT OF RISK FACTORS FOR DEVELOPMENTOF URETHRAL STRICTURES AND BLADDER NECK SCLEROSISIN PATIENTS WHO HAVE UNDERWENT SURGERYFOR BENIGN PROSTATE HYPERPLASIA

Abstract

Introduction. Urethral stricture and sclerosis of the bladder neck are the most common urological pathologies in men in
various countries. The main cause of strictures is urethral fibrosis due to sexually transmitted infections, pelvic injuries, and
surgical interventions.
The aim is to study the contribution of various risk factors to the development of urethral strictures and bladder sclerosis
in patients undergoing surgery for benign prostatic hyperplasia (BPH).
Materials and methods. We conducted a retrospective epidemiological study of the prevalence of late complications of
surgical intervention with calculation of odds ratio for each risk factors on a continuous sample of operated patients for three
years, from 2019 to 2021 (total 702 people). The critical level for significance of differences in groups was accepted as
p<0.05. All statistical analysis procedures were performed using SPSS 20.
Results. Urethral strictures and bladder neck sclerosis occurred in the postoperative period in 4.9% of patients. The
main risk factors with a statistically significant level were the emergency type of hospitalization (OR=0.015, p=0.006), the
presence of infectious inflammation before surgery (OR=0.624, p=0.042) and the amount of residual urine before surgery
(OR=1.014, p= 0.022). High OR rates were also typical for transurethral resection of prostate (TURP), overweight and
obesity, diabetes mellitus, and disease duration of more than a year.
Conclusion. When planning and performing surgical intervention for BPH, as well as when managing the patient in the
postoperative period, it is necessary to take into account risk factors for the development of urethral strictures and sclerosis
of the bladder neck in order to develop and implement preventive measures.