METHODS OF TREATMENT OF HYPERPROLACTINEMIA INCOMBINATION WITH HYPOTHYROISIS. LITERATURE REVIEW.

Abstract

Relevance. Menstrual disorders are the most common complaint in gynecological endocrinology, which can develop
against the background of hyperprolactinemia, thyroid disease, or a combination of these hormonal disorders. A rather
complex and not fully explored problem is the tactics of managing patients with a combination of hypothyroidism and
hyperprolactinemic hypogonadism.
Aim. To analyze the available literature on the treatment of hyperprolactinemia and hypothyroidism against the
background of menstrual disorders.
Search strategies. The article includes publications published in the database PubMed, Web of science, Google
Scholar and the scientific electronic library e-Library.ru for the keywords: hypothyroidism, hyperprolactinemia, menstrual
irregularity. The search depth was 10 years (2011–2021). Also, references to earlier works of scientific value were used. The
literature search included publications in Russian and English.
Results and conclusions. The article describes the main methods of treatment of hyperprolactaemic hypogonadism,
hypothyroidism, including subclinical, as well as their combination. Until now, the question of choosing the optimal tactics for managing patients with hypothyroidism and functional hyperprolactinemia has not been resolved. A number of authors point
out that in these cases it is sufficient to carry out replacement therapy with thyroid hormone preparations, which leads to the
normalization of the prolactin level and the regression of the corresponding clinical manifestations. Other authors advised to
additionally prescribe dopamine receptor agonists to suppress prolactin secretion.