CATECHOLAMINES AND THEIR METABOLITES IN REGULATION OFACTIVITY OF MITOCHONDRIAL AND CYTOPLASMIC HEART ENZYMS.LITERATURE REVIEW.

Abstract

Relevance. The review analyzes the literature data on the features of the participation of catecholamines and their
metabolites in the regulation of the activity of mitochondrial enzymes of cardiomyocytes - succinate dehydrogenase (SDH),
cytochrome c oxidase (CHO), ATPase and AMP deaminase (AMPD) and cytoplasmic enzymes of cardiomyocytes -
glutathione peroxidase (GPO), glutathione reductase (GR) catalase, adenosine deaminase (AD), AMP-deaminase (AMPD),
5-nucleotidase (5`H) and the content of lipid peroxidation products - malondialdehyde (MDA) and diene conjugates (DC). An
analysis of the literature on the study of the functional dependence of the activity of mitochondrial enzymes on the
metabolism of catecholamines was carried out.
Aim: to study to analyze the literature on the participation of catecholamines and their metabolites in the regulation of the activity of mitochondrial enzymes and cytoplasmic enzymes and the content of lipid peroxidation products.
Search strategy: Research papers were searched in the search engines Scopus, Web of Science Core Collection,
MedLine, PubMed, Cochrane Library, Google Scholar, in the electronic scientific library e-Library.ru, CyberLeninka. The
depth of the literature search was 20 years. Search filters were set: experimental studies performed on mice and rats over
the past 20 years, published in English and Russian, as well as full versions of articles with clearly formulated and
statistically proven conclusions.
Results and conclusions: An analysis of the literature data showed that hormones-mediators of the sympathoadrenal
system, by changing the activity of the enzymes of the respiratory chain of cardiomyocyte mitochondria, regulate the
processes of tissue respiration. In cardiomyocytes, adrenaline, by activating the cytosolic enzymes of the metabolism of
purine nucleotides AD and AMPD, increasing the level of lipid peroxidation (MDA and DC), increases the activity of the
antioxidant defense enzymes GPO and catalase, which indicates that adrenaline, through adrenoreceptor mechanisms,
leads the body to state of oxidative stress.