THE CLINICAL EFFECT OF PROBIOTIC-CONTAINING PRODUCT ON HEALTH INDICATORS AMONG A POPULATION OF CENTRAL ASIA
DOI:
https://doi.org/10.34689/m5j9d819Keywords:
synbiotic , metabolic syndrome , lipid profileAbstract
Introduction. The main goal is to test the efficacy of a synbiotic product which consists of the selected probiotic
strains (Lactobacillus plantarum, Lactobacillus fermentum, Lactobacillus acidophilus, Bifidobacterium longum,
Bifidobacterium bifidum), inulin, pectin, and fish collagen in adults diagnosed with metabolic syndrome.
Materials and methods. This double-blind placebo-controlled trial was conducted among 180 participants aged
25 to 75 years. Subjects with and without metabolic syndrome were randomly assigned to receive synbiotic or
placebo daily for three months. 134 of 180 participants completed the study.
Results. Compared with the placebo group, the synbiotic group had significantly decreased total cholesterol
(TC) from 5.16±0.95 to 4.86±0.86 mmol/L, due to lowering the levels of LDL and triglyceride (p <0.0005). The
present findings suggest positive influence of the tested synbiotic on controlling excess weight and in treating some
metabolic disorders in adults.
Conclusion We conclude that the presented synbiotic formulation here has potential within efforts to reduce the
risk and progression of the metabolic syndrome. This trial suggests beneficial effects of a synbiotic supplement for
controlling excess weight, as well as the progression of some metabolic disorders, as determined from circulating
levels of risk factor biomarkers among adults.
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Copyright (c) 2026 Алмагуль Кушугулова, Жаксыбай Жумадилов, Валерий Бенберин, Талгат Нургожин, Роза Бакенова, Раушан Карабаева, Салтанат Бейсембаева, Гульжанат Уразбаева, Сауле Садуахасова, Шынгыс Сергазы, Асхат Молкенов, Улыкбек Каиров, Самат Кожахметов, София Форсланд, Пир Борк (Автор)
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