ASSOCIATION OF POLYMORPHISMS OF GENESOF IL1B (RS1143627), IL10 (RS1800896),IL17А (RS 2275913, RS8193036) WITH INFECTIOUSDISEASES INCLUDING ERYSIPELAS

Abstract

The investigate of polymorphism of cytokine genes is an important in pathogenesis of many diseases
and in identifying susceptibility to them. Knowledge of their role in the pathogenesis of many diseases,
particularly infectious diseases are permits, on the one hand, to predict risk of disease or severity of its
flow, on the other - to pick up individually specific therapy for a particular patient.
Despite the fact that to date, in the literature there are a significant number of studies that found an
association between polymorphisms of cytokine genes and susceptibility to infectious diseases, the
opinions of the authors about of markers of predisposition or resistance to infections, depending on the
origin (viral or bacterial infection) are inconsistent.
The aim of this systematic review are analysis of publications on the association of polymorphisms
of cytokine genes (rs1143627, rs1800896 rs8193036, rs 2275913) with infectious diseases, including
erysipelas for identify the markers of susceptibility to infectious diseases.
Materials and methods. The study included full-text publications in English and Russian languages
over the past 10 years, which was investigated genetic markers to infectious diseases on the basis of
cytokine gene polymorphisms (rs1143627, rs8193036, rs 2275913, rs1800896).
Results. As a result, the search has been identified 786 sources in databases Pubmed, Scopus, e -
Library. After the screening were selected and included in the study 18 full-text articles.
Conclusions. Polymorphism of IL10 gene (rs1800896) plays key role at chronic viral hepatitis C.
Practicullar, GG genotype was associated with susceptibility to chronic viral hepatitis C. Allele T and TT
genotype of polymorphism rs1143627 of IL1B gene are poor factors of susceptibility, development and
current of infectious diseases, independent of genesis (viral or bacterial etiology).