MOLECULAR TYPE OF BREAST CANCERAS PROGNOSTIC FACTOR FOR METASTASIS(Literature review)

Abstract

Introduction: The article provides an overview of the literature data on the peculiarities of
metastasis of different subtypes of breast cancer (BC), which is characterized by heterogeneity,
malignancy, early and rapid lymphatic and hematogenous metastasis. Modern studies have shown
about the connection between the molecular type and localization of metastatic breast cancer.
Objective: Analysis of published data about the features of different molecular subtypes of breast
cancer metastasis.
Materials and Methods: publications searched in the following databases: PubMed Medline, Health
star, Embase, Cochrane depth from 2000 to 2016.
Results: Recent studies about metastatic breast cancer at the molecular types suggest that risk
stratification by subtypes can provide a more personalized, individual care for certain high-risk groups
metastasis. A literature review showed that the breast cancer subtypes have characteristics significantly
different metastasis and life expectancy after the onset of local and distant metastases.
Conclusions: These molecular genetic studies reflect the primary risk and susceptibility of certain
subtypes of breast cancer to metastasize to specific organs, which means determining the prognostic
significance of molecular subtypes of breast cancer metastasis to further search.