PREECLAMPSIA: NEW INFORMATION ABOUT THE PATHOGENESIS, DEFINITIONS AND RECOMMENDATIONS. REVIEW.

Abstract

Background. Hypertensive disorders of pregnancy - chronic hypertension, gestational hypertension and preeclampsia -
are a unique problem, since pathology and its therapeutic treatment simultaneously affect the mother and fetus, sometimes
putting their well-being in conflict with each other. Preeclampsia, in particular, is one of the most dangerous complications of
pregnancy. Often manifested as first-time hypertension and proteinuria during the third trimester of pregnancy, preeclampsia
can rapidly progress to serious complications, including death of both mother and fetus. Although the cause of preeclampsia
is still being debated, clinical and pathological studies show that the placenta plays a central role in the pathogenesis of this
syndrome.
Aim. To review the scientific literature sources on the pathogenesis and treatment of preeclampsia.
Search strategy. In this review we search full-text publications in English and Russian, which are devoted to the
pathogenesis and new recommendations for the treatment of preeclampsia. Next databases were used in the process of
literature search: Pubmed, Web of science, Cyberleninka, Google Scholar by keywords. The search period was 2000-2022
years. 1566 publications were identified on this topic. 46 articles corresponded to our research objective. Inclusion criteria:
Publications of the level of evidence A, B: meta-analyses, systematic reviews, cohort and cross-sectional studies. Exclusion
criteria: summary reports, newspaper articles and personal messages.
Results and conclusions. Preeclampsia is the leading cause of maternal morbidity and mortality worldwide, the only
definitive treatment for which - delivery of the fetus and placenta - leads to significant morbidity and mortality of newborns.