MOLECULAR PATTERNS OF FOOD ALLERGY IN CHILDREN: REVIEW

Abstract

Background: today molecular diagnosis is an innovative approach, used to characterize the molecular components of
each allergen that participate in allergic process and includes specific IgE mediators (sIgE). In clinical practice, component
diagnostics allows doctors to increase the accuracy of the clinical diagnosis, choose effective therapy and perform a
prognosis of the disease.
Aim of the study: to analyze published data regarding the prevalence and patterns of food allergies in children of
different ages.
Search strategy: Search for scientific publications in the search engines PubMed, Cochrane Library, GoogleScholar,
GoogleAcademia, in the electronic scientific library eLibrary.ru, CyberLeninka. Inclusion criteria: publications of Kazakhstan
authors, as well as scientific works from closest and far abroad; full-text epidemiological and clinical studies; the search
depth was 10 years (2010-2020) due to the importance of revealing the sequence of specific molecular allergy diagnosis
historical development. The study was carried out by next keywords searching: molecular allergy diagnosis, food allergy,
major food allergens, specific IgE. Preference was given to works with a high-quality design, such as cohort studies,
systematic reviews, meta-analysis. In case of absence, the results of cross-sectional studies were taken into account. Our
analysis included 56 works. Results: molecular allergological diagnosis is an important step in improving the accuracy of determination of IgEmediated sensitization in food allergies. The ability to correctly identify and characterize individual allergens at the molecular
level leads to a clear understanding of mechanisms in food sensitization.
Conclusions: New insights and trends regarding the sensitization process have been identified, new possibilities and
effectiveness of specific immunotherapy using recombinant allergens have been identified.