POLYMORPHISM OF IL10 GENE AT -1082G/A POSITIONIN PATIENTS WITH ERYSIPELAS

Abstract

The aim of this study is reveal the association of polymorphism of IL10 gene (rs1800896) at 1082
GA position with the erysipelas in Kazakh population.
Materials and methods. The polymorphism of IL10 gene (rs1800896) was assessed in 206 patients
with erysipelas and 422 control subjects. Of them 143 patients with primary erysipelas and 63 with
recurrence erysipelas. Genomic DNA was extracted from blood for genotyping. Genotyping of
polymorphism of IL10 gene (-1082 GA) was conducted by method of polymerase chain reaction in real
time. Pearson’s Chi tests and odds ratios (OR) with 95 % confidence intervals (CI) were using for
statistical analysis.
Our results showed that G allele and GG genotype more common in both group: in patients and in
control group (OR = 0.87; 95% CI: 0.68–1.12 and OR = 0.86; 95% CI: 0.61–1.19, respectively). Also
statistical significant differences by the frequency of occurrence of allele A (OR = 1.14; 95% CI: 0.89–
1.47) and AA (OR = 1.20; 95% CI: 0.73–2.00) genotype in patients with the control group are not
revealed. When comparing patients with primary erysipelas (case group) and control group, and
patients with recurrent erysipelas (case group) with a individuals of control group were also observed no
statistically significant results.
Conclusions. So, our results suggested that no association of polymorphism of IL10 gene
(rs1800896) at position -1082 GA with erysipelas in Kazakh population.