ENDOTHELIAL DYSFUNCTION OF LYMPHATIC VESSELS IN RATS WITH ACUTE PANCREATITIS AND ITS CORRECTION

Аңдатпа

Introduction. The problem of pancreatitis is one of the most important problems of modern medicine. The lymphatic system, being an integral part of the cardiovascular system, is involved in the pathological process. The clinical symptoms of acute pancreatitis are based on a number of pathophysiological changes, among which damage to the vascular endothelium plays an important role, which leads to endothelial dysfunction. There is insufficient information in the literature about the effect of acute pancreatitis on the functions of the lymphatic system, in particular on the functional state of the lymphatic vessels, and correction methods using sorbents of plant origin have not been studied from this point of view, which makes this study relevant. Aim. To study the contractile activity of lymphatic vessels in rats with acute pancreatitis and the correction of endothelial functions using a lignin-based plant sorbent. Research methods. The experiments were carried out on Wistar rats using: an installation for recording the contractile activity of isolated vessels, consisting of a thermostatic chamber, a mechanotron and a recording device (mechanotron 6Mx1B, 6Mx2B), a GOBOS INTEGRA 400 biochemical analyzer and a REO-Mizar rheography. Results. In acute pancreatitis, the contractile activity of isolated lymphatic vessels was suppressed due to inhibition of endothelial adrenergic receptors located in the endothelial layer. Application of lignin sorbent restored the contractile function of lymphatic vessels through endothelial restoration, presumably preventing nitric oxide inactivation. The action of the sorbent normalized the frequency-amplitude characteristics of contractile responses of lymphatic vessels in rats, as a result of which lymph circulation may improve. Conclusions. In acute pancreatitis and as a result of emerging endothelial dysfunction, the use of lignin-based sorbent is effective and cost-effective. It is advisable to use the sorbent in combination with therapeutic methods for the treatment of pathological conditions of the body, in particular acute pancreatitis.