PREDICTION OF THE SEVERITY OF PREECLAMPSIABASED ON URINARY PLACENTAL GROWTH FACTORCONCENTRATIONS IN THE FIRST TRIMESTER OF PREGNANCY:A PROSPECTIVE COHORT STUDY
DOI:
https://doi.org/10.34689/wp61ky58Keywords:
pregnancy , first trimester , placental growth factor , blood , urine , preeclampsia , severity of preeclampsiaAbstract
Objective: assessment of prediction of the severity of preeclampsia (PE) based on the concentration of placental growth
factor (PLGF) in urine in comparison with the concentrations of PLGF in the blood, determined in the first trimester of
pregnancy.
Materials and methods: it was a single-center prospective cohort study, included 288 pregnant women without risk
factors of PE, selected by a simple random sample. All subjects underwent general clinical examination and assessment of
previous health events. Diagnosis of PE and assessment of its severity were carried out according to the criteria of the
International Society for the Study of Hypertension in Pregnancy. PLGF levels in blood and urine were determined at a gestational age of 10-14 weeks by ELISA by the Dialab ELX808IU analyzer (Dialab, Austria) using Human Placental Growth
Factor ELISA Kit reagents (Sigma Aldrich, Germany).
Results: There were 2.4% (n = 7) mild PE, 2.8% (n = 8) severe PE, and 94.8% (n = 273) of patients were normotensive
during pregnancy. The concentrations of urinary PLGF were 7.97 (6.35-27.21) pg/ml in mild PE and was not statistically
different from normotensive patients, where the level of urinary PLGF was 21.4 (14.3-35.1) pg/ml, as well as with the level of
serum PLGF with mild PE (p> 0.05). In severe PE, urinary PLGF concentrations were 7.17 (5.24-16.2) pg/ml and were
statistically lower in comparison with normotensive pregnant women (p < 0.05) and with serum PLGF (p = 0.0233). ROCanalysis showed optimal cut-off levels in severe PE for urinary PLGF ≤ 10.8 pg/ml, with diagnostic indicators AUC 0.869, p
<0.0001, Se 71.4%, Sp 87.2%, DOR 16.8.
Conclusions: determination of urinary PLGF in the first trimester of pregnancy may be used to prediction of severe PE,
but not for mild PE, and may be used to develop express test systems. The limitations of this study warrant further study of
urinary PLGF to predict PE and its severity.
References
Гайдай А.Н., Тусупкалиев А.Б., Жумагулова С.С., Касаева Н.Е. Прогнозирование тяжести преэклампсии на
основании плацентарного фактора роста в моче в первом триместре беременности: проспективное когортное
исследование // Наука и Здравоохранение. 2021. 6(Т.23). С. 54-62. doi 10.34689/SH.2021.23.6.006
Gaidai A.N., Tusupkaliev A.B., Zhumagulova S.S., Kasaeva N.E. Prediction of the severity of preeclampsia based on
urinary placental growth factor concentrations in the first trimester of pregnancy: a prospective cohort study // Nauka i
Zdravookhranenie [Science & Healthcare]. 2021, (Vol.23) 6, pp. 54-62. doi 10.34689/SH.2021.23.6.006
Гайдай А.Н., Тусупкалиев А.Б., Жумагулова С.С., Касаева Н.Е. Жүктіліктің бірінші триместрінде зәрдегі
плацентарлық өсу факторы негізінде преэклампсия ауырлық дәрежесін болжау: проспективті когорттық зерттеу //
Ғылым және Денсаулық сақтау. 2021. 6 (Т.23). Б. 54-62. doi 10.34689/SH.2021.23.6.006
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Copyright (c) 2026 Андрей Гайдай, Акылбек Тусупкалиев, Сагира Жумагулова, Назерке Касаева (Автор)
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