STATE OF METABOLIC PROCESSES IN ORGANS OF RATSPROGENY EXPOSED TO γ-RADIATION

Abstract

Introduction: Absence of the scientifically worked out criteria of connection of the mediated
influence of radiation factor on the state of person’s health the parents of that were exposed to the direct
radiation-damage, stipulated actuality of realization of the real research.
The aim. To study of enzyme activity of energy metabolism and lipid peroxidation levels in
immunocompetent organs in progeny of rats exposed to radiation.
Materials and methods. Experimental studies were carried out on white outbred 130 rats of both
sexes. Irradiation was performed in czech radiotherapy device «Teragam» rays of 60Co. In
immunocompetent organs of animals were determined the activity of succinatedehydrogenase and
citochromoxidase, levels of malonic dialdehyde and diene conjugates. Results of the study were
manufactured by E.V. Montsevichyute-Eringene's methods of variation statistics.
Results. It is set that in 5-monthly descendants irradiated animals compared with healthy animal
activity decreases in thymus SDG to 23,45%, (p<0,05), adrenal glands tissue tends to increase, in
spleen has been on the decline in liver and the lymph nodes of the small intestine there is no reliable
changes. Results analysis of the research show that in 5-monthly descendants irradiated animals in
liver, in small intestinal lymph nodes, in adrenal glands activity CHO does not undergo reliable changes
in spleen, whereas a decline at 18,13% (p<0,05) in thymus at 21,05% (p<0,05). The 5-monthly
descendants irradiated animals in liver also reliable changes have been detected in spleen, although
there is bullishness in thymus, there has been a significant increase of DC at 25,39%, (p< 0,05), in small
intestinal lymph nodes and adrenal glands is a trend of increase. Quantitative content of MDA in 5-
monthly descendants irradiated animals in spleen decreases at 20,83% (p<0,05), in thymus is a trend of
increase in small intestinal lymph nodes, liver, adrenal glands reliable changes are observed. 

Conclusion. In investigational homogenats of liver, spleen, thymus, adrenal glands and small
intestinal lymph nodes of 5 monthly descendants of the rats exposed to the small dose of gammaradiation, activity of enzymes of SDG and CHO, and also quantitative maintenance of DC and MDA is
not suffered reliable changes.